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Three clinical trials based on their work have been halted after questions were raised by scientists who failed to replicate their results.
An Indian oncologist accused of falsely claiming he was a Rhodes scholar on applications for federal grants has been suspended by Duke University.
Separately, a letter signed by 31 researchers at universities all over the United States, accuses Anil Potti and his colleague Joseph Nevins at Duke’s Institute for Genome Sciences & Policy of “serious errors” in their 2006 claim of a “microarray analysis of patient tumors [that] could be used to predict response to chemotherapy.” Three clinical trials based on their work have been halted after questions were raised by scientists who failed to replicate their results. The British journal, Lancet Oncology, has issued an “expression of concern” over the December 2007 study it published from Anil Potti and his colleagues after two of the co-authors contacted it to express “grave concerns about the validity of their report.” In a letter to the National Cancer Institute, the 31 complaining scientists wrote that, “It is absolutely premature to use these prediction models to influence the therapeutic options open to cancer patients.” |
